tag:blogger.com,1999:blog-4624586630299165335.post3780288100886690034..comments2024-07-16T06:40:00.489+01:00Comments on Psychological comments: GWAS hits and country IQAnonymoushttp://www.blogger.com/profile/09320614837348759094noreply@blogger.comBlogger8125tag:blogger.com,1999:blog-4624586630299165335.post-130754045200294262016-01-22T01:43:24.300+00:002016-01-22T01:43:24.300+00:00Piffer seems to have reanalyzed his data and calcu...Piffer seems to have reanalyzed his data and calculated somewhat higher scores for Africans in both height and iq (if my reading is right). How significant the difference is between corrected and uncorrected iq projections, I cannot tell..<br /><br />"I computed two polygenic scores (mean population frequencies): ancestral and derived. Then I created a composite score by averaging them. This gives equal weight to ancestral and derived alleles (Piffer, 2015b).The end result is that populations with higher baseline frequencies of derived alleles (such as Africans) obtain a higher score after this correction, because more weight is given to ancestral alleles."<br /><br />"We can see that the ranking of corrected polygenic scores for height and IQ gives higher scores to Africans compared to the uncorrected scores..."<br /><br />https://topseudoscience.wordpress.com<br /><br />"Derived alleles,corrected polygenic scores and height"Jm8noreply@blogger.comtag:blogger.com,1999:blog-4624586630299165335.post-85810931655651856462015-11-17T09:06:26.695+00:002015-11-17T09:06:26.695+00:00I am afraid the author of the commentary got it wr...I am afraid the author of the commentary got it wrong this time. Different LD patterns should simply reduce the reliability of the cross-population comparison, but they should not bias the results towards lower polygenic scores for Africans. Apparently the author never heard of a thing called correction for reliability, which if done would actually increase the PS difference between Africans and Europeans. But there is no reason why different LD patterns would increase allele frequency differences between populations. The effect would actually be the opposite, as the real frequency differences are expected to be larger than those observed.Merculinushttps://www.blogger.com/profile/12533970814734366905noreply@blogger.comtag:blogger.com,1999:blog-4624586630299165335.post-74216396532288363752015-11-16T21:31:54.732+00:002015-11-16T21:31:54.732+00:00"Interpretation of SNP countings are difficul..."Interpretation of SNP countings are difficult due to differential linkage disequilibrium patterns across populations."<br /><br /><br />https://thewinnower.com/papers/2735-polygenic-scores-genetic-engineering-validity-of-gwas-results-across-major-racial-groups-and-the-piffer-method<br /><br /><br />"...Two reviews found substantial cross-validity for the Eurasian population (Europeans and East Asians), and less for Africans (usually African Americans) (23,24). The first review only relied on SNPs with p<α and found weaker results. This is expected because using only these is a threshold effect, as discussed earlier.<br /><br />The second review (from 2013; 299 included GWAS) found much stronger results, probably because it included more SNPs and because they also adjusted for statistical power. Doing so, they found that: ~100% of SNPs replicate in other European samples when accounting for statistical power, ~80% in East Asian samples but only ~10% in the African American sample (not adjusted for statistical power, which was ~60% on average). There were fairly few GWAS for AAs however, so some caution is needed in interpreting the number. Still, this throws some doubt on the usefulness of GWAS results from Europeans or Asians used on African samples (or reversely)."<br /><br />"7. POOR AFRICAN-EURASIAN CROSS-VALIDITY AND THE PIFFER METHOD<br /><br />The findings related to the relatively poor, but non-zero cross-validity of GWAS betas between European and African samples throw some doubt on the SNP evidence found by Piffer in his studies of the population/country IQ and cognitive ability SNP factors (29). If the betas for the SNPs identified in European sample GWAS do not work well as predictors for Africans, they would be equally unsuitable for estimating mean genotypic cognitive ability from SNP frequencies. Thus, further research is needed to more precisely estimate the cross-racial validity of GWAS betas, especially with regards to African vs. Eurasian samples."just86https://www.blogger.com/profile/12968717584019022506noreply@blogger.comtag:blogger.com,1999:blog-4624586630299165335.post-23471863387022111272015-09-05T14:19:50.473+01:002015-09-05T14:19:50.473+01:00Review for Intell takes a mean of 200 days.
We ar...Review for Intell takes a mean of 200 days.<br /><br />We are working on using polygenic scores now using all the SNPs.<br /><br />We will of course jump at the SSGAC hits when they come out. Hopefully, they publish the entire list of betas like Rietveld 2013, so one can calculate polygenic scores.Emil O. W. Kirkegaardhttps://www.blogger.com/profile/06373127088976173644noreply@blogger.comtag:blogger.com,1999:blog-4624586630299165335.post-10365949131604966372015-09-04T16:40:35.594+01:002015-09-04T16:40:35.594+01:00The whisker on the far right box is also odd. Terr...The whisker on the far right box is also odd. Terry Tao, is that you?Aeoli Perahttps://www.blogger.com/profile/12578422091389930117noreply@blogger.comtag:blogger.com,1999:blog-4624586630299165335.post-11179709802732255462015-09-04T07:57:13.639+01:002015-09-04T07:57:13.639+01:00The leftmost box is the odd one out. But I'll...The leftmost box is the odd one out. But I'll try very hard not to notice.deariemenoreply@blogger.comtag:blogger.com,1999:blog-4624586630299165335.post-24644435695504787442015-09-04T06:12:37.592+01:002015-09-04T06:12:37.592+01:00Don't let the policymakers hear about this...:...Don't let the policymakers hear about this...:pelijahlarmstrongnoreply@blogger.comtag:blogger.com,1999:blog-4624586630299165335.post-88759465591066332652015-09-03T18:44:11.244+01:002015-09-03T18:44:11.244+01:00Or download it at http://emilkirkegaard.dk/en/wp-c...Or download it at http://emilkirkegaard.dk/en/wp-content/uploads/PifferIntelligence2015.pdf<br /><br />I wonder if this would have been more convincing if he'd waited for the SSGAC hits supposedly coming out sometime this year? But I suppose he can always do a followup paper and this must have taken long enough to get finished as it is.gwernhttps://www.blogger.com/profile/18349479103216755952noreply@blogger.com